Okaramine A, a novel indole alkaloid with insecticidal activity, from Penicillium simplicissimum AK-40.
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چکیده
منابع مشابه
GluCl a target of indole alkaloid okaramines: a 25 year enigma solved
In 1989, indole alkaloid okaramines isolated from the fermentation products of Penicillium simplicissimum were shown to be insecticidal, yet the mechanism of their toxicity to insects remains unknown. We therefore examined the action of okaramine B on silkworm larval neurons using patch-clamp electrophysiology. Okaramine B induced inward currents which reversed close to the chloride equilibrium...
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Four new okaramine congeners, okaramines J, K, L and M, were isolated from okara fermented with Penicillium simplicissimum ATCC 90288, together with five biogenetically related compounds, cyclo (8a-(α,α-dimethylallyl)-L-Trp-8a-(α,α-dimethylallyl)-L-Trp), cyclo (N (8)-(α,α-dimethylallyl)-L-Trp-6a'-(α,α-dimethylallyl)-L-Trp), cyclo (L-Trp-L-Trp), cyclo (6a'-(α,α-dimethylallyl)-L-Trp-L-Trp), and c...
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متن کاملThiersinines A and B: novel antiinsectan indole diterpenoids from a new fungicolous Penicillium species (NRRL 28147).
[structure: see text] Two novel antiinsectan indole diterpenoids, thiersinines A (1) and B (2), along with seven known paxilline-type compounds, were isolated from organic extracts of a new Penicillium species (P. thiersii NRRL 28147). The structures of 1 and 2 were determined by analysis of 2D NMR data. Thiersinines A and B possess a unique spirocyclic subunit that is unprecedented in previous...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1988
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.52.885